产品
编 号:F170041
分子式:C17H28Cl3N5
分子量:408.8
产品类型
结构图
CAS No: 146509-94-6
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产品详情
生物活性:
Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli.
体外研究:
Olanexidine 显示出以下杀菌机制:(i) 与细菌表面分子相互作用,如脂多糖和脂磷壁酸;(ii) 破坏脂质体的细胞膜,这是人工细菌膜模型;(iii) 增强大肠杆菌的膜通透性;(iv) 破坏金黄色葡萄球菌的膜完整性,以及 (v) 在相对高浓度 (≥160 μg/ml) 下使蛋白质变性。