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编 号:F170041
分子式:C17H28Cl3N5
分子量:408.8
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1mg
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5mg
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10mg
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25mg
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50mg
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生物活性:
Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli.

体外研究:
Olanexidine 显示出以下杀菌机制:(i) 与细菌表面分子相互作用,如脂多糖和脂磷壁酸;(ii) 破坏脂质体的细胞膜,这是人工细菌膜模型;(iii) 增强大肠杆菌的膜通透性;(iv) 破坏金黄色葡萄球菌的膜完整性,以及 (v) 在相对高浓度 (≥160 μg/ml) 下使蛋白质变性。
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