产品
编 号：F168850
分子式：C22H20Cl2N4O3
分子量：459.33
分子式：C22H20Cl2N4O3
分子量：459.33
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CAS No: 146033-02-5
产品详情
生物活性：
SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity.
体内研究：
SC 51089 (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷。Animal Model:R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age
Dosage:40 μg/kg/day
Administration:Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:Ameliorated motor coordination and balance dysfunction.Rescued long-term memory deficit.Improved the expression of specific synaptic markers.Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.
体外研究：
SC 51089 (5 μM; 24 h) 减弱前列腺素 E2 (PGE2) 诱导的暴露于 t-BuOOH 的神经元细胞死亡。
SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity.
体内研究：
SC 51089 (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷。Animal Model:R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age
Dosage:40 μg/kg/day
Administration:Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:Ameliorated motor coordination and balance dysfunction.Rescued long-term memory deficit.Improved the expression of specific synaptic markers.Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.
体外研究：
SC 51089 (5 μM; 24 h) 减弱前列腺素 E2 (PGE2) 诱导的暴露于 t-BuOOH 的神经元细胞死亡。
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