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编 号:F168412
分子式:C23H21N7O
分子量:411.46
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.

体内研究:
Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats.

体外研究:
Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro.IC50 for inhibition of specific binding of 125I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM.
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