产品
编 号：F168291
分子式：C24H21Cl2N3OS3
分子量：534.54
分子式：C24H21Cl2N3OS3
分子量：534.54
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
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询价
结构图
CAS No: 1456551-16-8
产品详情
生物活性：
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
体内研究：
JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.Animal Model:6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:3 mg/kg
Administration:Intraperitoneal injection; on days 0, 2, and 4
Result:Limited tumor growth, but somewhat less effectively.
体外研究：
JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM.JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells.JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27.
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
体内研究：
JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.Animal Model:6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:3 mg/kg
Administration:Intraperitoneal injection; on days 0, 2, and 4
Result:Limited tumor growth, but somewhat less effectively.
体外研究：
JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM.JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells.JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27.
产品资料
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