产品
编 号：F168044
分子式：C11H13N5Na4O9P2
分子量：513.16
分子式：C11H13N5Na4O9P2
分子量：513.16
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CAS No: 1454889-37-2
产品详情
生物活性：
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.
体内研究：
MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time.Animal Model:CL57BLr6 mice
Dosage:50 mg/kg
Administration:Injection into the jugular vein of mice
Result:The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.
体内研究：
MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time.Animal Model:CL57BLr6 mice
Dosage:50 mg/kg
Administration:Injection into the jugular vein of mice
Result:The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
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