产品
编 号：F167999
分子式：C21H26N6O3
分子量：410.47
分子式：C21H26N6O3
分子量：410.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1454808-95-7
产品详情
生物活性：
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.
体内研究：
在小鼠中，LP-922761 的脑血浆比为 0.007，表明 LP-922761 基本上局限于外周隔室。
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.
体内研究：
在小鼠中，LP-922761 的脑血浆比为 0.007，表明 LP-922761 基本上局限于外周隔室。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备