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编 号：F167584
分子式：C14H17ClN4S
分子量：308.83
分子式：C14H17ClN4S
分子量：308.83
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CAS No: 145231-45-4
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生物活性：
Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock.
体内研究：
Clobenpropit (15 mg/kg；腹腔注射；每天一次，持续 7 天) 可抵消 MK-801 (HY-15084B) 对多巴胺和组胺水平的调节作用，并防止 MK-801 诱导的过度运动行为。Clobenpropit (1、2、5 μmoL/kg；静脉注射) 对遭受失血性休克的大鼠产生复苏作用。Animal Model:150-200g, 12-week-old male wistar albino rats
Dosage:15 mg/kg
Administration:I.p.; once daily for 7 days
Result:Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus.
Animal Model:205-470g, adult male Wistar rats
Dosage:1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days)
Administration:I.v.
Result:Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg).
Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock.
体内研究：
Clobenpropit (15 mg/kg；腹腔注射；每天一次，持续 7 天) 可抵消 MK-801 (HY-15084B) 对多巴胺和组胺水平的调节作用，并防止 MK-801 诱导的过度运动行为。Clobenpropit (1、2、5 μmoL/kg；静脉注射) 对遭受失血性休克的大鼠产生复苏作用。Animal Model:150-200g, 12-week-old male wistar albino rats
Dosage:15 mg/kg
Administration:I.p.; once daily for 7 days
Result:Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus.
Animal Model:205-470g, adult male Wistar rats
Dosage:1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days)
Administration:I.v.
Result:Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg).
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