产品
编 号：F167265
分子式：C13H12ClN3O4S
分子量：341.77
分子式：C13H12ClN3O4S
分子量：341.77
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1451272-71-1
产品详情
生物活性：
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
体内研究：
1.19Mouse PK parameters for SBI-425 CompdsSBI-425
Clp (mL/min/kg)5.14
Vd (L/kg)1.03
Cmax (μg/mL)178
AUC (μg*hr/mL)848
t1/2 (hr)2.3
%F58
体外研究：
SBI-425 treatment suppresses Foxp3 expression in CD4+ and CD8+ T cells in splenocytes from CLP-injured mice.
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
体内研究：
1.19Mouse PK parameters for SBI-425 CompdsSBI-425
Clp (mL/min/kg)5.14
Vd (L/kg)1.03
Cmax (μg/mL)178
AUC (μg*hr/mL)848
t1/2 (hr)2.3
%F58
体外研究：
SBI-425 treatment suppresses Foxp3 expression in CD4+ and CD8+ T cells in splenocytes from CLP-injured mice.
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