产品
编 号：F167083
分子式：C33H34N6O6
分子量：610.66
分子式：C33H34N6O6
分子量：610.66
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
440
In-stock
1g
680
In-stock
结构图
CAS No: 145040-37-5
产品详情
生物活性：
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.
体内研究：
Candesartan Cilexetil (5 mg/kg，灌胃，一天一次，连续 7 周) 可改善高盐喂养的 Dahl 盐敏感 (DS) 大鼠的心肌重构和心力衰竭。Candesartan Cilexetil (1-10 mg/kg，口服，一天一次，连续15 天) 对大鼠皮肤创面愈合有促进作用。Candesartan Cilexetil (1-10 mg/kg，胃管给药，一天一次，持续 4-12 周) 可抑制自发性高血压大鼠的血压升高。 Candesartan Cilexetil (10 mg/kg，口服，饮水中补充，持续2-23 天) 可抑制 bleomycin (HY-108345) 诱导的大鼠肺纤维化模型中 TGF-b1 的合成，改善肺纤维化。Animal Model:Dahl salt-sensitive hypertensive rats
Dosage:5 mg/kg
Administration:Oral gavage (p.o.)
Result:Increased body weight and decreased left ventricular end-diastolic diameter.Decreased the level of iNOS mRNA and ADM mRNA in the left ventricle (LV).Increased the eNOS protein mass in the LV and decreased the immunoreactive ADM contents of LV.Enhanced immunoreactivity for eNOS.Significantly decreased the degree of perivascular fibrosis.
Animal Model:Skin wound model rat
Dosage:1 mg/kg, 10 mg/kg
Administration:Oral
Result:Showed 100% re-epithelization of the wound at 1 mg/kg.Significantly suppressed angiogenesis at 10 mg/kg.
体外研究：
Candesartan Cilexetil (0.1-10 μM, 24 h) 在 HUVEC 细胞、HEK293T 细胞中均表现出对 ZIKV 的抗病毒作用。
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.
体内研究：
Candesartan Cilexetil (5 mg/kg，灌胃，一天一次，连续 7 周) 可改善高盐喂养的 Dahl 盐敏感 (DS) 大鼠的心肌重构和心力衰竭。Candesartan Cilexetil (1-10 mg/kg，口服，一天一次，连续15 天) 对大鼠皮肤创面愈合有促进作用。Candesartan Cilexetil (1-10 mg/kg，胃管给药，一天一次，持续 4-12 周) 可抑制自发性高血压大鼠的血压升高。 Candesartan Cilexetil (10 mg/kg，口服，饮水中补充，持续2-23 天) 可抑制 bleomycin (HY-108345) 诱导的大鼠肺纤维化模型中 TGF-b1 的合成，改善肺纤维化。Animal Model:Dahl salt-sensitive hypertensive rats
Dosage:5 mg/kg
Administration:Oral gavage (p.o.)
Result:Increased body weight and decreased left ventricular end-diastolic diameter.Decreased the level of iNOS mRNA and ADM mRNA in the left ventricle (LV).Increased the eNOS protein mass in the LV and decreased the immunoreactive ADM contents of LV.Enhanced immunoreactivity for eNOS.Significantly decreased the degree of perivascular fibrosis.
Animal Model:Skin wound model rat
Dosage:1 mg/kg, 10 mg/kg
Administration:Oral
Result:Showed 100% re-epithelization of the wound at 1 mg/kg.Significantly suppressed angiogenesis at 10 mg/kg.
体外研究：
Candesartan Cilexetil (0.1-10 μM, 24 h) 在 HUVEC 细胞、HEK293T 细胞中均表现出对 ZIKV 的抗病毒作用。
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