产品
编 号：F166994
分子式：C15H18ClNS2
分子量：311.89
分子式：C15H18ClNS2
分子量：311.89
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1449686-84-3
产品详情
生物活性：
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.
体内研究：
Tipepidine (ip；10-40 mg/kg；0.5-23 hours) 显著减少 ACTH 处理大鼠在强迫游泳试验中的不动时间。Tipepidine (ip；40 mg/kg) 增加 ACTH 处理大鼠伏隔核 (NAc) 的细胞外多巴胺水平。Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old)
Dosage:10, 20 and 40 mg/kg
Administration:I.p.; 0.5, 5, 23 hours
Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.
体内研究：
Tipepidine (ip；10-40 mg/kg；0.5-23 hours) 显著减少 ACTH 处理大鼠在强迫游泳试验中的不动时间。Tipepidine (ip；40 mg/kg) 增加 ACTH 处理大鼠伏隔核 (NAc) 的细胞外多巴胺水平。Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old)
Dosage:10, 20 and 40 mg/kg
Administration:I.p.; 0.5, 5, 23 hours
Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
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