产品
编 号:F166816
分子式:C30H46O4
分子量:470.68
产品类型
结构图
CAS No: 1449-05-4
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产品详情
生物活性:
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis.
体内研究:
18α-Glycyrrhetinic acid (18α-GA) treatmentsignificantly enhances life span of C. elegans strains with the most effective concentration being 20?μg/mL. Results reveal a significant delay of paralysis upon 18α-Glycyrrhetinic acid treatment. 18α-Glycyrrhetinic acid treatment also confers a significant reduction of Aβ deposits.
体外研究:
18α-Glycyrrhetinic acid (18a-GA) markedly reduces LX-2 cell numbers by 14.8% and 31.2% after 48 h and 72 h of treatment, respectively (P18α-Glycyrrhetinic acid 相关抗体: