产品
编 号：F166446
分子式：C16H12O3
分子量：252.26
分子式：C16H12O3
分子量：252.26
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CAS No: 1448009-94-6
产品详情
生物活性：
CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis.
体内研究：
CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects.Animal Model:Five-week-old female athymic nude mice (BALB/c-nu)
Dosage:20 mg/kg
Administration:i.v., every other day for two weeks
Result:Showed antitumor effects.
体外研究：
CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 μM for MCF-7 and MCF7/ADR cells, respectively. CS1 (10, 50, 100 μM) inhibits the activity of topoisomerase II α (Topo IIα).CS1 (0-20 μM) shows antiproliferation activity in cancer cells.CS1 (2.5, 5, 10 μM) induces cell cycle arrest at the G2/M phase.CS1 (2.5, 5, 10 μM) induces cell apoptosis.CS1 (5, 10, 15 μM; 24 h) induces DNA breaks in MDA-MB-231 cells.
CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis.
体内研究：
CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects.Animal Model:Five-week-old female athymic nude mice (BALB/c-nu)
Dosage:20 mg/kg
Administration:i.v., every other day for two weeks
Result:Showed antitumor effects.
体外研究：
CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 μM for MCF-7 and MCF7/ADR cells, respectively. CS1 (10, 50, 100 μM) inhibits the activity of topoisomerase II α (Topo IIα).CS1 (0-20 μM) shows antiproliferation activity in cancer cells.CS1 (2.5, 5, 10 μM) induces cell cycle arrest at the G2/M phase.CS1 (2.5, 5, 10 μM) induces cell apoptosis.CS1 (5, 10, 15 μM; 24 h) induces DNA breaks in MDA-MB-231 cells.
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