产品
编 号:F165952
分子式:C24H27N5O2
分子量:417.5
产品类型
结构图
CAS No: 1446311-56-3
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产品详情
生物活性:
SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research.
体内研究:
SMN-C2 (20 mg/kg, daily)可以替代 SMN2 剪接转向 FL mRNA,导致小鼠大脑和脊髓中 SMN 蛋白水平增加。