产品
编 号：F018350
分子式：C36H44N4O
分子量：548.76
分子式：C36H44N4O
分子量：548.76
产品类型
规格
价格
是否有货
结构图
CAS No: 104196-68-1
产品详情
生物活性：
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1.
体内研究：
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days.Animal Model:Plasmodium berghei in infected mice
Dosage:50 or 100 mol/kg
Administration:Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:Inhibited the growth of the rodent malaria parasite Plasmodium berghei.Prolonged the survival of highly parasitaemic mice.
体外研究：
Manzamine A (5-50 μM, 18 h) decreases tau phosphorylation, measured with ELISA.Manzamine A (10 μM) inhibits yeast S. cerevisiae growth by 30%.Manzamine A displays a few enlarged vacuoles in yeast.Manzamine A (2.5-10 μM, 24 h) increases acidity in pancreatic cancer cells and non-malignant Vero cells.Manzamine A (1 μM, 24 h) inhibits HSV-1 infection in SIRC cells.Manzamine A shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1.
体内研究：
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days.Animal Model:Plasmodium berghei in infected mice
Dosage:50 or 100 mol/kg
Administration:Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:Inhibited the growth of the rodent malaria parasite Plasmodium berghei.Prolonged the survival of highly parasitaemic mice.
体外研究：
Manzamine A (5-50 μM, 18 h) decreases tau phosphorylation, measured with ELISA.Manzamine A (10 μM) inhibits yeast S. cerevisiae growth by 30%.Manzamine A displays a few enlarged vacuoles in yeast.Manzamine A (2.5-10 μM, 24 h) increases acidity in pancreatic cancer cells and non-malignant Vero cells.Manzamine A (1 μM, 24 h) inhibits HSV-1 infection in SIRC cells.Manzamine A shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备