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编 号：F165711
分子式：C34H38N4O6
分子量：598.69
分子式：C34H38N4O6
分子量：598.69
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CAS No: 14459-29-1
产品详情
生物活性：
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.
体内研究：
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130
Dosage:5, 10 mg/kg
Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).
体外研究：
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC50s of 85 and 166 nM, respectively.Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.
体内研究：
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130
Dosage:5, 10 mg/kg
Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).
体外研究：
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC50s of 85 and 166 nM, respectively.Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
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