产品
编 号：F165679
分子式：C24H24F2N6O3
分子量：482.48
分子式：C24H24F2N6O3
分子量：482.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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结构图
CAS No: 1445830-39-6
产品详情
生物活性：
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.
体外研究：
BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel.
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.
体外研究：
BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel.
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