产品
编 号：F018303
分子式：C20H30O2
分子量：302.45
分子式：C20H30O2
分子量：302.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
440
In-stock
100mg
600
In-stock
500mg
2400
In-stock
结构图
CAS No: 10417-94-4
产品详情
生物活性：
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.
体外研究：
C/EBPβ 磷酸化形式在 Eicosapentaenoic Acid (EPA；100 μM；24 小时) 处理的细胞中很明显，而在对照和 OA 或 LA 处理的 U937 中几乎检测不到。 Eicosapentaenoic Acid (100 μM；1，3，24 h) 导致 H-Ras 和 N-Ras mRNA 水平显著增加，持续 1 和 3 小时。K-Ras mRNA 水平不受 Eicosapentaenoic Acid 的影响。
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.
体外研究：
C/EBPβ 磷酸化形式在 Eicosapentaenoic Acid (EPA；100 μM；24 小时) 处理的细胞中很明显，而在对照和 OA 或 LA 处理的 U937 中几乎检测不到。 Eicosapentaenoic Acid (100 μM；1，3，24 h) 导致 H-Ras 和 N-Ras mRNA 水平显著增加，持续 1 和 3 小时。K-Ras mRNA 水平不受 Eicosapentaenoic Acid 的影响。
产品资料
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