产品
编 号：F164474
分子式：C17H14F2N4O
分子量：328.32
分子式：C17H14F2N4O
分子量：328.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
560
In-stock
10mg
880
In-stock
25mg
1840
In-stock
50mg
2800
In-stock
100mg
4240
In-stock
结构图
CAS No: 1443246-62-5
产品详情
生物活性：
ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy.
体内研究：
ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.Animal Model:8-10 months old C57/BL6 male mice (approximately 30 g)
Dosage:60 mg/kg
Administration:Intraperitoneal injection
Result:Most of the animals neither convulsions nor death.
体外研究：
ML 297 is completely inactive for GIRK2/3.ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3.
ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy.
体内研究：
ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.Animal Model:8-10 months old C57/BL6 male mice (approximately 30 g)
Dosage:60 mg/kg
Administration:Intraperitoneal injection
Result:Most of the animals neither convulsions nor death.
体外研究：
ML 297 is completely inactive for GIRK2/3.ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备