产品
编 号：F018140
分子式：C19H17N6NaO5S3
分子量：528.56
分子式：C19H17N6NaO5S3
分子量：528.56
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 104146-53-4
产品详情
生物活性：
Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
体内研究：
Pharmacokinetics in mice：Cefditoren (mg/kg)C0 (μg/ml)t1/2 (h)AUClast (μg× h/ml)Tlast (h)
6.2553.00.930.46
12.5168.41.164.18
25232.50.9101.38
50290.61.1124.48
体外研究：
Cefditoren (sodium) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis.OrganismMIC50 (mg/L)MIC90 (mg/L)susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae(untyped)a0.015-0.250.12-1
PS≤0.008-0.030.015-0.2599-100
PI0.06-0.50.25-0.594-100
PR0.25-10.5-27-100
S. pyogenes≤0.008-0.03 0.015-0.03100
Staphylococcus aureus (MS) 0.12-0.5 0.5-150-100
Gram-negative organisms
Haemophilus≤0.008-≤0.030.015-0.13
influenzae (untyped)b
β-Lactamase +≤0.008-0.030.015-0.06100
β-Lactamase -≤0.008-0.030.015-0.06100
H. parainfluenzaeb≤0.030.06
Moraxella0.03-0.5 0.25-196
catarrhalis (untyped)b
β-Lactamase +≤0.03-0.250.12-0.5100
β-Lactamase -≤0.008-0.030.015-0.06100
a Including PS, PI and PR strains.b Including both β-lactamase-positive and -negative strains.MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.
Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
体内研究：
Pharmacokinetics in mice：Cefditoren (mg/kg)C0 (μg/ml)t1/2 (h)AUClast (μg× h/ml)Tlast (h)
6.2553.00.930.46
12.5168.41.164.18
25232.50.9101.38
50290.61.1124.48
体外研究：
Cefditoren (sodium) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis.OrganismMIC50 (mg/L)MIC90 (mg/L)susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae(untyped)a0.015-0.250.12-1
PS≤0.008-0.030.015-0.2599-100
PI0.06-0.50.25-0.594-100
PR0.25-10.5-27-100
S. pyogenes≤0.008-0.03 0.015-0.03100
Staphylococcus aureus (MS) 0.12-0.5 0.5-150-100
Gram-negative organisms
Haemophilus≤0.008-≤0.030.015-0.13
influenzae (untyped)b
β-Lactamase +≤0.008-0.030.015-0.06100
β-Lactamase -≤0.008-0.030.015-0.06100
H. parainfluenzaeb≤0.030.06
Moraxella0.03-0.5 0.25-196
catarrhalis (untyped)b
β-Lactamase +≤0.03-0.250.12-0.5100
β-Lactamase -≤0.008-0.030.015-0.06100
a Including PS, PI and PR strains.b Including both β-lactamase-positive and -negative strains.MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.
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