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编 号：F164132
分子式：C21H34N2O5
分子量：394.51
分子式：C21H34N2O5
分子量：394.51
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CAS No: 1441000-45-8
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生物活性：
Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain.
体内研究：
Opiranserin（25 mg/kg，皮下注射）可有效减少机械性异常性疼痛和疼痛相关行为，其功效与 3 mg/kg Morphine相当。Opiranserin（80 mg/kg，口服）可减轻大鼠 SNL 模型中的机械性异常性疼痛。
Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain.
体内研究：
Opiranserin（25 mg/kg，皮下注射）可有效减少机械性异常性疼痛和疼痛相关行为，其功效与 3 mg/kg Morphine相当。Opiranserin（80 mg/kg，口服）可减轻大鼠 SNL 模型中的机械性异常性疼痛。
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