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编 号：F163478
分子式：C176H271N53O54
分子量：3993.36
分子式：C176H271N53O54
分子量：3993.36
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CAS No: 143863-88-1
产品详情
生物活性：
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
体内研究：
Neuropeptide Y (3-36) (porcine) (0.24-24 nM; i.c.v.; single dose) induces feeding in the rat in a dose-dependent manner. Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss).Animal Model:Adult male Wistar rats (250-300 g)
Dosage:0.24, 0.72, 2.4, 7.2, 24 nM per animal
Administration:Intracerebroventricular injection; single dose
Result:Stimulated rat feeding dose-dependently.Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.
体外研究：
Neuropeptide Y (3-36) (porcine) accounts for 35% of NPY-like immunoreactivity in porcine brain.? Neuropeptide Y (3-36) (porcine) shows high affinity for Y2-like receptors on CHP234 cells, andlight affinity Y1-like receptors on SK-N-MC cells.
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
体内研究：
Neuropeptide Y (3-36) (porcine) (0.24-24 nM; i.c.v.; single dose) induces feeding in the rat in a dose-dependent manner. Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss).Animal Model:Adult male Wistar rats (250-300 g)
Dosage:0.24, 0.72, 2.4, 7.2, 24 nM per animal
Administration:Intracerebroventricular injection; single dose
Result:Stimulated rat feeding dose-dependently.Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.
体外研究：
Neuropeptide Y (3-36) (porcine) accounts for 35% of NPY-like immunoreactivity in porcine brain.? Neuropeptide Y (3-36) (porcine) shows high affinity for Y2-like receptors on CHP234 cells, andlight affinity Y1-like receptors on SK-N-MC cells.
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