产品
编 号：F163471
分子式：C34H34ClN3O5
分子量：600.1
分子式：C34H34ClN3O5
分子量：600.1
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 143851-98-3
产品详情
生物活性：
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer.
体内研究：
Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma.1.19Plasma Pharmacokinetic Parameters of Elacridar hydrochloride in mice.MicePO 100 mg/kg MiceIP 100 mg/kg MiceIV 2.5 mg/kg
CL/F (ml/min)2.0533.20.46
Vd/F (liter)3.512.30.17
t1/2 (h)204.34.4
AUC0-inf (μg·min/ml)146090.3161.4
F 0.220.0131
Animal Model:FVB wild-type mice
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg once
Result:Showd a higher concertration in brain than plasma except at 4 h after administration.
体外研究：
Elacridar hydrochloride (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells.Elacridar hydrochloride (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines.Elacridar hydrochloride (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells.
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer.
体内研究：
Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma.1.19Plasma Pharmacokinetic Parameters of Elacridar hydrochloride in mice.MicePO 100 mg/kg MiceIP 100 mg/kg MiceIV 2.5 mg/kg
CL/F (ml/min)2.0533.20.46
Vd/F (liter)3.512.30.17
t1/2 (h)204.34.4
AUC0-inf (μg·min/ml)146090.3161.4
F 0.220.0131
Animal Model:FVB wild-type mice
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg once
Result:Showd a higher concertration in brain than plasma except at 4 h after administration.
体外研究：
Elacridar hydrochloride (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells.Elacridar hydrochloride (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines.Elacridar hydrochloride (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备