产品
编 号：F163456
分子式：C22H21Cl2N3O4
分子量：462.33
分子式：C22H21Cl2N3O4
分子量：462.33
产品类型
规格
价格
是否有货
1mg
160
In-stock
5mg
400
In-stock
10mg
720
In-stock
25mg
1600
In-stock
50mg
2560
In-stock
100mg
4560
In-stock
结构图
CAS No: 1438416-21-7
产品详情
生物活性：
MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity.
体内研究：
MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg.Animal Model:Male C57BL/6J mice ranged from 18 to 35 g
Dosage:0.0818 mg/kg
Administration:I.p.; twice daily for 5.5 days
Result:Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.
体外研究：
MJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively.
MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity.
体内研究：
MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg.Animal Model:Male C57BL/6J mice ranged from 18 to 35 g
Dosage:0.0818 mg/kg
Administration:I.p.; twice daily for 5.5 days
Result:Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.
体外研究：
MJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively.
产品资料
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