产品
编 号:F163450
分子式:C43H69NO13
分子量:808.01
产品类型
结构图
CAS No: 143839-74-1
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产品详情
生物活性:
L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans.
体外研究:
L685818 (100 nM; MPP+ 组处理 2 天, 6-OHDA组处理 24 h) 具有神经保护作用,在 MPP+ 和 6-OHDA 抑制下,增加 TH+ 细胞的数目。L685818 (10-100 nM; 24 h) 防止 MPP+ 和 6-OHDA (HY-B1081) 处理引起的酪氨酸羟化酶 (TH) 损失。L685818 (0.01-1 μM; 24 h) 防止 MPP+ 和 6-OHDA 导致神经元突起的收缩和丢失,促进突起再生。