产品
编 号：F163069
分子式：C34H33N3O5
分子量：563.64
分子式：C34H33N3O5
分子量：563.64
产品类型
规格
价格
是否有货
1mg
190
In-stock
5mg
380
In-stock
10mg
608
In-stock
50mg
1824
In-stock
100mg
3200
In-stock
200mg
4880
In-stock
结构图
CAS No: 143664-11-3
产品详情
生物活性：
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer.
体内研究：
Elacridar (100 mg/kg; i.p. once) shows different distribution in brain and plasma.1.19Plasma Pharmacokinetic Parameters of Elacridar in mice.MicePO 100 mg/kg MiceIP 100 mg/kg MiceIV 2.5 mg/kg
CL/F (ml/min)2.0533.20.46
Vd/F (liter)3.512.30.17
t1/2 (h)204.34.4
AUC0-inf (μg?min/ml)146090.3161.4
F 0.220.0131
Animal Model:FVB wild-type mice.
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg once
Result:Showd a higher concertration in brain than plasma except at 4 h after the dose.
体外研究：
Elacridar (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells.Elacridar (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines.Elacridar (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells.
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer.
体内研究：
Elacridar (100 mg/kg; i.p. once) shows different distribution in brain and plasma.1.19Plasma Pharmacokinetic Parameters of Elacridar in mice.MicePO 100 mg/kg MiceIP 100 mg/kg MiceIV 2.5 mg/kg
CL/F (ml/min)2.0533.20.46
Vd/F (liter)3.512.30.17
t1/2 (h)204.34.4
AUC0-inf (μg?min/ml)146090.3161.4
F 0.220.0131
Animal Model:FVB wild-type mice.
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg once
Result:Showd a higher concertration in brain than plasma except at 4 h after the dose.
体外研究：
Elacridar (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells.Elacridar (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines.Elacridar (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备