产品
编 号：F163036
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规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
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CAS No: 143653-53-6
产品详情
生物活性：
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.
体内研究：
Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia.Animal Model:Male Wistar rats weighing 200-250 g, balloon angioplasty model
Dosage:0.25 mg/kg/day
Administration:Intravenous injection, 28 days
Result:Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB2 concentration.
体外研究：
Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin.Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them.
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.
体内研究：
Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia.Animal Model:Male Wistar rats weighing 200-250 g, balloon angioplasty model
Dosage:0.25 mg/kg/day
Administration:Intravenous injection, 28 days
Result:Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB2 concentration.
体外研究：
Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin.Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them.
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