产品
编 号：F161802
分子式：C18H20N4
分子量：292.38
分子式：C18H20N4
分子量：292.38
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 143257-98-1
产品详情
生物活性：
Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats.
体内研究：
Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vds of 0.88-0.96 L, MRT0-LAST of 224-337.1 min and AUC∞ of 57.7-66.1 μg·min/L in rats.Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia.Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats.IV (50 μg/kg) IV (100 μg/kg) IV (200 μg/kg)
CL (L/min)0.0050.0040.004
Vds (L)0.90.880.96
MRT0-LAST (min)224337.1226.3
AUC∞ (μg·min/L)66.157.758.1
Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats.
体内研究：
Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vds of 0.88-0.96 L, MRT0-LAST of 224-337.1 min and AUC∞ of 57.7-66.1 μg·min/L in rats.Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia.Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats.IV (50 μg/kg) IV (100 μg/kg) IV (200 μg/kg)
CL (L/min)0.0050.0040.004
Vds (L)0.90.880.96
MRT0-LAST (min)224337.1226.3
AUC∞ (μg·min/L)66.157.758.1
产品资料
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