产品
编 号：F161787
分子式：C34H32Cl2N4O4Sn
分子量：750.26
分子式：C34H32Cl2N4O4Sn
分子量：750.26
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 14325-05-4
产品详情
生物活性：
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.
体内研究：
Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.Animal Model:Male and female athymic nude mice with PDAC cell-derived xenograft tumors
Dosage:5 mg/kg
Administration:Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result:Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
体外研究：
Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.
体内研究：
Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.Animal Model:Male and female athymic nude mice with PDAC cell-derived xenograft tumors
Dosage:5 mg/kg
Administration:Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result:Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
体外研究：
Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
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