产品
编 号：F161755
分子式：C18H15FN4O
分子量：322.34
分子式：C18H15FN4O
分子量：322.34
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是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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CAS No: 1432436-13-9
产品详情
生物活性：
VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140?nM) for the research of schizophrenia.
体内研究：
VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration.Animal Model:Male C57BL6/J mice (8-9 weeks old)
Dosage:1, 3, or 10?mg/kg
Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test
Result:Rescued deficits in social interaction observed in PCP-treated mice.
体外研究：
Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140?nM) for the research of schizophrenia.
体内研究：
VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration.Animal Model:Male C57BL6/J mice (8-9 weeks old)
Dosage:1, 3, or 10?mg/kg
Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test
Result:Rescued deficits in social interaction observed in PCP-treated mice.
体外研究：
Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
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