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编 号：F002030
分子式：C17H12F2N2O3
分子量：330.29
分子式：C17H12F2N2O3
分子量：330.29
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CAS No: 100325-51-7
产品详情
生物活性：
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects.
体内研究：
CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells.
体外研究：
CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells.CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL.
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects.
体内研究：
CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells.
体外研究：
CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells.CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL.
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