产品
编 号：F160817
分子式：C23H23N3O2
分子量：373.45
分子式：C23H23N3O2
分子量：373.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1429505-03-2
产品详情
生物活性：
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research.
体内研究：
Soticlestat 处理以剂量依赖性方式降低大脑 24S-羟基胆固醇，并在将大脑 24S-羟基胆固醇降低约 50% 的剂量下显著减少 APP/PS1-Tg 小鼠的过早死亡。Soticlestat 可以抑制钾诱发的海马细胞外谷氨酸升高。Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)
Dosage:10 mg/kg
Administration:Oral administration; once daily; for 1 days, 3 days and 7 days
Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
体外研究：
Soticlestat 以浓度依赖性方式抑制人胆固醇 24-羟化酶 (CH24H) 的催化活性，IC50 为 4.5 nM。
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research.
体内研究：
Soticlestat 处理以剂量依赖性方式降低大脑 24S-羟基胆固醇，并在将大脑 24S-羟基胆固醇降低约 50% 的剂量下显著减少 APP/PS1-Tg 小鼠的过早死亡。Soticlestat 可以抑制钾诱发的海马细胞外谷氨酸升高。Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)
Dosage:10 mg/kg
Administration:Oral administration; once daily; for 1 days, 3 days and 7 days
Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
体外研究：
Soticlestat 以浓度依赖性方式抑制人胆固醇 24-羟化酶 (CH24H) 的催化活性，IC50 为 4.5 nM。
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