产品
编 号：F160562
分子式：C20H28N4O4
分子量：388.46
分子式：C20H28N4O4
分子量：388.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
In-stock
2mg
询价
In-stock
5mg
询价
In-stock
10mg
询价
In-stock
50mg
询价
In-stock
结构图
CAS No: 142880-36-2
产品详情
生物活性：
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
体内研究：
Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting.
体外研究：
Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis?of 0.4 nM, 20 nM, 20 nM, resepctively.?Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing.
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
体内研究：
Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting.
体外研究：
Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis?of 0.4 nM, 20 nM, 20 nM, resepctively.?Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing.
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