产品
编 号：F160516
分子式：C15H13NO2
分子量：239.27
分子式：C15H13NO2
分子量：239.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
150
In-stock
5mg
300
In-stock
10mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 1428-67-7
产品详情
生物活性：
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.
体内研究：
DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.Animal Model:Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models
Dosage:10 μg/rat
Administration:Subcutaneous injections, daily, for 11 days
Result:Increased swimming and decreased immobility in the FST.
体外研究：
DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα).?DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons.?DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.?DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner.?DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons.?DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38.
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.
体内研究：
DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.Animal Model:Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models
Dosage:10 μg/rat
Administration:Subcutaneous injections, daily, for 11 days
Result:Increased swimming and decreased immobility in the FST.
体外研究：
DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα).?DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons.?DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.?DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner.?DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons.?DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38.
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