产品
编 号：F160495
分子式：C25H42O6
分子量：438.6
分子式：C25H42O6
分子量：438.6
产品类型
规格
价格
是否有货
500μg
询价
询价
结构图
CAS No: 142861-00-5
产品详情
生物活性：
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome.
体内研究：
Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity.Animal Model:BALB/c mice (bearing SVT2 murine fibrosarcoma)
Dosage:1 mg/kg
Administration:I.p.; once
Result:Showed significant antitumor activity on day 4.
体外研究：
Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM.Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively.
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome.
体内研究：
Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity.Animal Model:BALB/c mice (bearing SVT2 murine fibrosarcoma)
Dosage:1 mg/kg
Administration:I.p.; once
Result:Showed significant antitumor activity on day 4.
体外研究：
Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM.Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively.
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