产品
编 号：F159337
分子式：C23H18Cl2F3NO4S
分子量：532.36
分子式：C23H18Cl2F3NO4S
分子量：532.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1426802-50-7
产品详情
生物活性：
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.
体内研究：
GSK805 (10 mg/kg; p.o. once per day for 35 days) improves the situation of mice with experimental autoimmune encephalomyelitis (EAE).GSK805 (30 mg/kg; p.o. once) inhibits Th17 cell responses in EAE mice.Animal Model:C57BL/6 mice were immunized with MOG35–55 plus CFA
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once per day; for 35 days
Result:Efficiently ameliorated the severity of EAE in mice.
Animal Model:C57BL/6 mice with EAE
Dosage:30 mg/kg
Administration:Oral gavage; 30 mg/kg once
Result:Reduced both IFN-γ-IL-17+ and IFN-γ+IL-17+ T cells without altered the frequency of TNF-α+ T cells in EAE mice.
体外研究：
GSK805 (0.5 μM; 4 d) inhibits Th17 cell responses.
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.
体内研究：
GSK805 (10 mg/kg; p.o. once per day for 35 days) improves the situation of mice with experimental autoimmune encephalomyelitis (EAE).GSK805 (30 mg/kg; p.o. once) inhibits Th17 cell responses in EAE mice.Animal Model:C57BL/6 mice were immunized with MOG35–55 plus CFA
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once per day; for 35 days
Result:Efficiently ameliorated the severity of EAE in mice.
Animal Model:C57BL/6 mice with EAE
Dosage:30 mg/kg
Administration:Oral gavage; 30 mg/kg once
Result:Reduced both IFN-γ-IL-17+ and IFN-γ+IL-17+ T cells without altered the frequency of TNF-α+ T cells in EAE mice.
体外研究：
GSK805 (0.5 μM; 4 d) inhibits Th17 cell responses.
产品资料
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