产品
编 号：F158929
分子式：C22H18N2O3
分子量：358.39
分子式：C22H18N2O3
分子量：358.39
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CAS No: 1425944-22-4
产品详情
生物活性：
CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer.
体内研究：
CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth.CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models.Animal Model:Female nude mice with MDA-MB-231 tumor xenografts
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg; once daily for 7 days
Result:Exhibited a 57% inhibition rate of MDA-MB-231 tumor growth in vivo.
体外研究：
CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells.CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines.
CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer.
体内研究：
CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth.CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models.Animal Model:Female nude mice with MDA-MB-231 tumor xenografts
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg; once daily for 7 days
Result:Exhibited a 57% inhibition rate of MDA-MB-231 tumor growth in vivo.
体外研究：
CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells.CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines.
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