产品
编 号：F158676
分子式：C5H8NNaO4
分子量：169.11
分子式：C5H8NNaO4
分子量：169.11
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规格
价格
是否有货
100mg
320
In-stock
500mg
480
In-stock
结构图
CAS No: 142-47-2
产品详情
生物活性：
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases.
体内研究：
L-Glutamic acid monosodium salt (3 g/kg, 皮下注射) 在小鼠中可促进视网膜神经节细胞的兴奋毒性变性。L-Glutamic acid monosodium salt (750 mg/kg, 腹腔注射) 在大鼠中可以减轻和抑制有机磷杀虫剂毒死蜱 (CPF) 诱导的氧化应激反应。Animal Model:Crv4 mice model
Dosage:3g/kg
Administration:s.c., single dose
Result:Reduced the number of Brn-3a+ RGCs by >70%.In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.
Animal Model:CPF-induced rat model
Dosage:750 mg/kg
Administration:i.p.
Result:Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
体外研究：
L-Glutamic acid monosodium salt (120, 500, 750, 1000 mg/dL) 可降低锂对非洲爪蟾胚胎发育的有害影响。L-Glutamic acid monosodium salt (2, 5, 10, 20 mM, 24-48 h) 在神经母细胞瘤中可诱导神经兴奋毒性。
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases.
体内研究：
L-Glutamic acid monosodium salt (3 g/kg, 皮下注射) 在小鼠中可促进视网膜神经节细胞的兴奋毒性变性。L-Glutamic acid monosodium salt (750 mg/kg, 腹腔注射) 在大鼠中可以减轻和抑制有机磷杀虫剂毒死蜱 (CPF) 诱导的氧化应激反应。Animal Model:Crv4 mice model
Dosage:3g/kg
Administration:s.c., single dose
Result:Reduced the number of Brn-3a+ RGCs by >70%.In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.
Animal Model:CPF-induced rat model
Dosage:750 mg/kg
Administration:i.p.
Result:Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
体外研究：
L-Glutamic acid monosodium salt (120, 500, 750, 1000 mg/dL) 可降低锂对非洲爪蟾胚胎发育的有害影响。L-Glutamic acid monosodium salt (2, 5, 10, 20 mM, 24-48 h) 在神经母细胞瘤中可诱导神经兴奋毒性。
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