产品
编 号：F158389
分子式：C21H14ClNO3
分子量：363.79
分子式：C21H14ClNO3
分子量：363.79
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
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询价
结构图
CAS No: 142326-59-8
产品详情
生物活性：
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity.
体内研究：
L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice.L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus.L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations.Animal Model:Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; daily, for 2 weeks
Result:Reduced the immobility of C57BL/6 J mice.Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model:Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model:Male Sprague-Dawley rats (280-300 g)
Dosage:2.5 and 5 mg/kg
Administration:Oral administration; once
Result:Increased in the percentage of time spent in the open arm in a dose-dependent.Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity.
体内研究：
L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice.L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus.L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations.Animal Model:Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; daily, for 2 weeks
Result:Reduced the immobility of C57BL/6 J mice.Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model:Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model:Male Sprague-Dawley rats (280-300 g)
Dosage:2.5 and 5 mg/kg
Administration:Oral administration; once
Result:Increased in the percentage of time spent in the open arm in a dose-dependent.Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
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