产品
编 号：F156668
分子式：C59H96O26
分子量：1221.38
分子式：C59H96O26
分子量：1221.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 14216-03-6
产品详情
生物活性：
Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity.
体内研究：
Hederacoside C (0.625, 1.25, 2.5 mg/kg, 腹腔注射, 连续 7 天) 可减轻 TNBS 诱导的肠炎 。Hederacoside C (5, 10, 50 mg/kg, 腹腔注射, 连续 3 次, 持续时间 8 h) 可减弱金黄色葡萄球菌引起的乳腺病变。Animal Model:TNBS-induced colitis in rat
Dosage:0.625, 1.25, 2.5 mg/kg
Administration:i.p. for 7 days
Result:Decreased the levels of inflammatory cytokines, including TNF-α, IL-6, IL-1β, CXCL-1, CXCL-2, and CXCL-5.Reduced cell apoptosis in TNBS-induced colitis.Reduced Bax/Bcl-2 ratio, cleaved caspase 3, and p53 protein levels in a dose-dependent manner.
体外研究：
Hederacoside C (0.1, 1, 10 μM, 1 h) 在人肠上皮 Caco-2 细胞中抑制 MAPK/NF-κB 及其下游信号通路的激活减轻炎症反应。Hederacoside C (5, 10, 50 μg/mL, 1 h) 对金黄色葡萄球菌刺激的 RAW 264.7 细胞有抗炎作用。Hederacoside C (5, 10 μg/mL, 2 h) 对小鼠软骨细胞衰老诱导的 ECM 降解具有保护作用。
Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity.
体内研究：
Hederacoside C (0.625, 1.25, 2.5 mg/kg, 腹腔注射, 连续 7 天) 可减轻 TNBS 诱导的肠炎 。Hederacoside C (5, 10, 50 mg/kg, 腹腔注射, 连续 3 次, 持续时间 8 h) 可减弱金黄色葡萄球菌引起的乳腺病变。Animal Model:TNBS-induced colitis in rat
Dosage:0.625, 1.25, 2.5 mg/kg
Administration:i.p. for 7 days
Result:Decreased the levels of inflammatory cytokines, including TNF-α, IL-6, IL-1β, CXCL-1, CXCL-2, and CXCL-5.Reduced cell apoptosis in TNBS-induced colitis.Reduced Bax/Bcl-2 ratio, cleaved caspase 3, and p53 protein levels in a dose-dependent manner.
体外研究：
Hederacoside C (0.1, 1, 10 μM, 1 h) 在人肠上皮 Caco-2 细胞中抑制 MAPK/NF-κB 及其下游信号通路的激活减轻炎症反应。Hederacoside C (5, 10, 50 μg/mL, 1 h) 对金黄色葡萄球菌刺激的 RAW 264.7 细胞有抗炎作用。Hederacoside C (5, 10 μg/mL, 2 h) 对小鼠软骨细胞衰老诱导的 ECM 降解具有保护作用。
产品资料
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