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编 号：F156394
分子式：C18H27NO5
分子量：337.41
分子式：C18H27NO5
分子量：337.41
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CAS No: 1421-14-3
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Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general anesthetic agent. Propanidid can decrease the arterial pressure.
体内研究：
Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons.Animal Model:Adult cats (immobilized by D-tubocurarine)
Dosage:3-5 mg/kg
Administration:Injected into the femoral vein; single dosage
Result:A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.
Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general anesthetic agent. Propanidid can decrease the arterial pressure.
体内研究：
Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons.Animal Model:Adult cats (immobilized by D-tubocurarine)
Dosage:3-5 mg/kg
Administration:Injected into the femoral vein; single dosage
Result:A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.
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