产品
编 号：F155897
分子式：C15H15Cl2N3O5
分子量：388.2
分子式：C15H15Cl2N3O5
分子量：388.2
产品类型
规格
价格
是否有货
100mg
询价
询价
500mg
询价
询价
结构图
CAS No: 1420-04-8
产品详情
生物活性：
Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.
体内研究：
氯硝柳胺钠 (灌胃; 100 mg/kg, 200 mg/kg;一周一次; 8周) 处理抑制肾上腺皮质癌肿瘤在体内生长。Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells
Dosage:100 mg/kg, 200 mg/kg
Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
体外研究：
氯硝柳胺 (0.6 nM-46 μ M) 处理可抑制 BD140A、SW-13 和 NCI-H295R 细胞的肾上腺皮质癌细胞增殖。氯硝柳胺(0.05-5 μM, 24 h) 处理抑制 STAT3 介导的 HeLa 细胞荧光素酶报告活性。氯硝柳胺 (10 μM) 处理抑制病毒在 Vero E6 细胞中的复制。
Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.
体内研究：
氯硝柳胺钠 (灌胃; 100 mg/kg, 200 mg/kg;一周一次; 8周) 处理抑制肾上腺皮质癌肿瘤在体内生长。Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells
Dosage:100 mg/kg, 200 mg/kg
Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
体外研究：
氯硝柳胺 (0.6 nM-46 μ M) 处理可抑制 BD140A、SW-13 和 NCI-H295R 细胞的肾上腺皮质癌细胞增殖。氯硝柳胺(0.05-5 μM, 24 h) 处理抑制 STAT3 介导的 HeLa 细胞荧光素酶报告活性。氯硝柳胺 (10 μM) 处理抑制病毒在 Vero E6 细胞中的复制。
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