产品
编 号：F016880
分子式：C20H17FN4O3
分子量：380.37
分子式：C20H17FN4O3
分子量：380.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1038984-31-4
产品详情
生物活性：
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.
体内研究：
Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) 在 CORT 小鼠模型中具有抗焦虑样和抗抑郁样作用。Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) 逆转双侧嗅球切除术诱导的小鼠多动和焦虑。Animal Model:chronic corticosterone administration (CORT) mice
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Oral gavage (p.o.)
Result:Reversed anxio-depressive phenotype in a neurogenesis-dependent task.Decreased the corticosterone-induced increase in emotionality.Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model.Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.
Animal Model:bilateral olfactory bulbectomy mice model
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly reverted OB-induced hyperactivity after 28 days. Increased open field central activity in OB mice.
体外研究：
Tulrampator (0.1 μM, 2 days) 显著增强谷氨酸诱发电流的幅度，延长 HEK-293 细胞的反应时间。Tulrampator (0.1-10 μM, 24 h) 对大鼠原代皮质细胞无毒性。
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.
体内研究：
Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) 在 CORT 小鼠模型中具有抗焦虑样和抗抑郁样作用。Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) 逆转双侧嗅球切除术诱导的小鼠多动和焦虑。Animal Model:chronic corticosterone administration (CORT) mice
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Oral gavage (p.o.)
Result:Reversed anxio-depressive phenotype in a neurogenesis-dependent task.Decreased the corticosterone-induced increase in emotionality.Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model.Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.
Animal Model:bilateral olfactory bulbectomy mice model
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly reverted OB-induced hyperactivity after 28 days. Increased open field central activity in OB mice.
体外研究：
Tulrampator (0.1 μM, 2 days) 显著增强谷氨酸诱发电流的幅度，延长 HEK-293 细胞的反应时间。Tulrampator (0.1-10 μM, 24 h) 对大鼠原代皮质细胞无毒性。
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