产品
编 号：F155585
分子式：C23H26N4O2
分子量：390.48
分子式：C23H26N4O2
分子量：390.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1418308-27-6
产品详情
生物活性：
EI1 (KB-145943) is a potent and selective?EZH2?inhibitor with?IC50?of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
体外研究：
In DLBCL cells, EI1 (KB-145943) inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 (KB-145943) also inhibit H3K27me3 and cell proliferation. In addition, EI1 (KB-145943) selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.
EI1 (KB-145943) is a potent and selective?EZH2?inhibitor with?IC50?of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
体外研究：
In DLBCL cells, EI1 (KB-145943) inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 (KB-145943) also inhibit H3K27me3 and cell proliferation. In addition, EI1 (KB-145943) selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.
产品资料
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