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编 号：F154405
分子式：C26H29Cl2NO
分子量：442.42
分子式：C26H29Cl2NO
分子量：442.42
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CAS No: 14158-65-7
产品详情
生物活性：
Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.
体内研究：
Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol.Animal Model:21 days-old Charles River male rats
Dosage:0.25 and 0.5 mg/animal, daily for 24 days.
Administration:Subcutaneous injection
Result:Decreased LH and testosterone levels in the serum.
Animal Model:OVX (ovariectomy) rat model
Dosage:0.03, 1, and 3 mg/kg, daily for 90 days.
Administration:Oral adminstration
Result:Reducted body weight to sham levels, and reduced serum cholesterol.Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
体外研究：
Enclomiphene hydrochloride (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene hydrochloride (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene hydrochloride (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.
Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.
体内研究：
Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol.Animal Model:21 days-old Charles River male rats
Dosage:0.25 and 0.5 mg/animal, daily for 24 days.
Administration:Subcutaneous injection
Result:Decreased LH and testosterone levels in the serum.
Animal Model:OVX (ovariectomy) rat model
Dosage:0.03, 1, and 3 mg/kg, daily for 90 days.
Administration:Oral adminstration
Result:Reducted body weight to sham levels, and reduced serum cholesterol.Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
体外研究：
Enclomiphene hydrochloride (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene hydrochloride (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene hydrochloride (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.
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