产品
编 号：F153381
分子式：C18H20O3
分子量：284.35
分子式：C18H20O3
分子量：284.35
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CAS No: 141172-08-9
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生物活性：
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin.
体内研究：
SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation.Animal Model:BALB/c mice using EAC cells.
Dosage:15 mg/kg.
Administration:Orally on every alternate day for 9 doses.
Result:There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
体外研究：
SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines.SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation.
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin.
体内研究：
SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation.Animal Model:BALB/c mice using EAC cells.
Dosage:15 mg/kg.
Administration:Orally on every alternate day for 9 doses.
Result:There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
体外研究：
SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines.SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation.
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