产品
编 号:F153007
分子式:C20H16Cl2N4
分子量:383.27
产品类型
结构图
CAS No: 140926-75-6
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产品详情
生物活性:
NSC5844 (RE-640) is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.
体外研究:
NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively.