产品
编 号：F152595
分子式：C4H8N4O2
分子量：144.13
分子式：C4H8N4O2
分子量：144.13
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规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
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询价
100mg
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询价
结构图
CAS No: 140-79-4
产品详情
生物活性：
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568.
体内研究：
N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice.Animal Model:BABL/c nude mice injected with labeled 6-10B cell suspensions (1?×?104?cells) with or without DNP(40 mg/kg)
Dosage:40 mg/kg
Administration:Injected into the tail veins; 30 days
Result:Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo.
体外研究：
N,N'-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8?μM concentration range. However, it is cytotoxic from the concentration 10 μM.N,N'-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6?μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%.N,N'-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells.
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568.
体内研究：
N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice.Animal Model:BABL/c nude mice injected with labeled 6-10B cell suspensions (1?×?104?cells) with or without DNP(40 mg/kg)
Dosage:40 mg/kg
Administration:Injected into the tail veins; 30 days
Result:Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo.
体外研究：
N,N'-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8?μM concentration range. However, it is cytotoxic from the concentration 10 μM.N,N'-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6?μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%.N,N'-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells.
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