产品
编 号：F152443
分子式：C22H27MnN4Na3O14P2
分子量：757.32
分子式：C22H27MnN4Na3O14P2
分子量：757.32
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 140678-14-4
产品详情
生物活性：
Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy.
体内研究：
Mangafodipir trisodium (10 mg/kg；腹腔注射，一次) 显示出对顺铂和紫杉醇引起的小鼠卵巢损伤的保护作用。Animal Model:Female CD-1(ICR) Mice with cisplatin- and paclitaxel-induced ovarian damage
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg, once
Result:Attenuated the loss of primordial follicles, reduction of secondary follicles and increase of antral follicles. Prevented the change of primary follicles caused by cisplatin and paclitaxel. Reduced the increasing of cleaved caspase-3 levels caused by cisplatin and paclitaxel.
体外研究：
Mangafodipir trisodium (40, 200 和 1000 μM) 抑制 H2O2 对 HGrC 细胞活力的影响。Mangafodipir trisodium (200 和 1000 μM) 减少顺铂诱导的 HGrC 细胞凋亡。
Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy.
体内研究：
Mangafodipir trisodium (10 mg/kg；腹腔注射，一次) 显示出对顺铂和紫杉醇引起的小鼠卵巢损伤的保护作用。Animal Model:Female CD-1(ICR) Mice with cisplatin- and paclitaxel-induced ovarian damage
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg, once
Result:Attenuated the loss of primordial follicles, reduction of secondary follicles and increase of antral follicles. Prevented the change of primary follicles caused by cisplatin and paclitaxel. Reduced the increasing of cleaved caspase-3 levels caused by cisplatin and paclitaxel.
体外研究：
Mangafodipir trisodium (40, 200 和 1000 μM) 抑制 H2O2 对 HGrC 细胞活力的影响。Mangafodipir trisodium (200 和 1000 μM) 减少顺铂诱导的 HGrC 细胞凋亡。
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