产品
编 号：F151942
分子式：C25H25FN2O3S
分子量：452.54
分子式：C25H25FN2O3S
分子量：452.54
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 1403838-79-8
产品详情
生物活性：
BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC50=22 μM) in an in vitro DNA cleavage assay.
体外研究：
BRD0539 dose-dependently blocks the formation of the DNA-bound state in a dose-dependent fashion.BRD0539 impairs the perturbation induced by the 4PAM DNA.BRD0539 does not interfere with the SpCas9:gRNA interaction.BRD0539 is able to inhibit SpCas9 in the eGFP-disruption assay, BRD0539 is unable to inhibit FnCpf1, a structurally different CRISPR-associated nuclease, in the same assay, further highlighting the specificity of BRD0539.
BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC50=22 μM) in an in vitro DNA cleavage assay.
体外研究：
BRD0539 dose-dependently blocks the formation of the DNA-bound state in a dose-dependent fashion.BRD0539 impairs the perturbation induced by the 4PAM DNA.BRD0539 does not interfere with the SpCas9:gRNA interaction.BRD0539 is able to inhibit SpCas9 in the eGFP-disruption assay, BRD0539 is unable to inhibit FnCpf1, a structurally different CRISPR-associated nuclease, in the same assay, further highlighting the specificity of BRD0539.
产品资料
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