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编 号:F151657
分子式:C18H26N6OS
分子量:374.5
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
GV-58 is a novel N- and P/Q-type calcium (Ca2+) channel agonist with EC50s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca2+ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research.

体外研究:
GV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction.
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